This hotel is located right next to the Cathedral of Barcelona, a main spot where there are things going on every day: Sardanas (a popular catalan dance), little markets and all sorts of street performers.
The Regencia Colón is right in the heart of the Gothic quarter so you will easily find the main museums after a short walk (such as Frederic Marés, City History Museum and Picasso Museum) as well as the main monuments and goverment buildings.
A perfectly located hotel for your visit to the city.